Novobrace Advantage

Novobrace vs. Stem Cell/PRP

Novobrace as a complement to Stem Cell/PRP treatment for tendon and ligament injuries in horses.

The two current stalwarts of interventional therapy for soft tissue injuries in horses are treatment with stem cells (SC) or platelet-rich plasma (PRP). These biological treatment modalities augment healing by providing, in the case of PRP, natural signaling molecules (or cytokines) that instruct the cells within the tissue to begin the healing process. SCs, in contrast, introduce additional cells into the tissue that can turn into the kind of cells necessary for repair, as well as themselves producing and secreting their own cytokines into the injury. Since these are biological processes, however, they require significant time to regenerate the new tissue and do little to provide immediate clinical benefits. During the initial months post-injury, therefore, the animal is unable to exercise and is generally restricted to stall rest while simultaneously being more susceptible to re-injury or enlargement of the original lesion.

Novobrace in Lesions

Novobrace works in an entirely different way. By reacting with and reinforcing the tissue surrounding the injury within minutes of injection, it immediately forms a stabilizing brace within the tissue itself. This brace acts to support the animal as it moves and to prevent propagation of the injury within the tissue, significantly reducing stall confinement times and accelerating return to work even as the injury heals. As a result, Novobrace can not only be used alone to complement the natural healing process, but also as an ideal adjunct to SC or PRP therapy where it provides immediate stabilization and the perfect healing environment for these slower-acting biological treatments to take effect. The different time-scales and modes-of-action of Novobrace and SCs/PRP complement each other perfectly to provide the best possible clinical outcome for the horse.

Regenerative therapy Stem Cell PRP differential to Novobrace for tendonitis and desmitis

Differential clinical effects of biological and Novobrace therapies.

Stem Cell PRP Novobrace NEXT therapy horse tendonitis desmitis

Schematic timeline of clinical benefits between Novobrace and biological therapies. Combining therapies maximizes clinical benefits to the horse by providing both immediate structural support and longer-term biologic-enhanced healing.

Novobrace in Tendonitis/Desmitis

In severe tendon and ligament injuries the collagen fibers that constitute the bulk of the tissue have been physically torn apart to form a lesion that must subsequently be filled during the healing process. In contrast acute and chronic tendonitis and desmitis represent less severe injuries where the collagen fibers have begun to fray but have not yet completely separated. This fraying is caused by the breaking of naturally occurring linkages between the collagen molecules that normally hold the structure together and confer mechanical strength to the tissue. In this weakened, state progression to lesion formation is much more likely and as a result, the animal must be rested while the damage is repaired. One of the final stages of this process is the strengthening of the collagen fibers and the production of new crosslinks, which is why recovery times can be lengthy.

Unlike in the case of lesions, both SCs and PRPs have shown limited clinical efficacy in treating tendonitis and desmitis. In contrast, Novobrace is ideally suited to such cases and represents the first real solution to this common problem. Novobrace mimics the natural process of crosslink formation, it is able to repair frayed crosslinks immediately, while still aiding subsequent production of new collagen within the tissue. Treatment with Novobrace reduces the risk of the formation of lesions and allows animals to return to work faster than normal, reducing both stall confinement and rehabilitation times significantly.