Product Information

novobrace product vials equine medical device
What does the Novobrace device look like?

Novobrace, a soft tissue injectable bioadhesive device to treat equine tendonitis and desmitis consists of two vials, one containing a non-toxic protein crosslinking agent and the other a proprietary buffered carrier solution.  The active ingredient in Novobrace is all natural Genipin.  Read our complete product insert for more information.

Gardenia Flower with Seed Pod (inset) Genipin
What is Genipin?

Genipin is the most abundant chemical component of, and is derived from, the seed pods of the Gardenia.  Discovered in the 1960s, Genipin is an aglycone extracted from the fruit of the Gardenia jasminoides ellis.  Genipin has long been recognized as a naturally occurring material that offers many biological applications, including its use as a cross-linking agent.

Genipin creates crosslinks when introduced to chemical groups called amines which are abundant on the polymer chains that make up all proteins, including collagen.  A cross-link is a bond that links one polymer chain to another.  Tendons and ligaments are made up of tightly packed collagen chains packed into fibers, and when genipin is injected into an injured tendon or ligament, Novobrace reacts with the polymer chains forming a series of intramolecular and intermolecular crosslinks and thus a flexible, chemical brace to help provide mechanical support. This brace helps to heal the injury much like a cast helps heal a broken bone.

Genipin molecule gardenia novobrace
Is Genipin safe?

Yes, Genipin is a safe crosslinking agent.  It is all natural, environmentally friendly and exhibits low toxicity.1-4   In fact, it is commonly used as a blue food colorant in East Asia.  When Genipin is introduced to any amine group in the presence of oxygen it forms a blue pigment.  This is why we recommend that you wear gloves when handling Novobrace and wash your skin that comes into contact with the product.

Molecular structure of Genipin shown left.

Molecular Formula: C11H14O5           Weight: 226.226 g/mol

Download The Science Behind Novobrace here.

Download Product Detail Sheet here.

References 1-4

1.    Aburada M, Miyamoto K, Aburada C, et al. Pharmacological studies of gardenia fruit (4). Toxicity test of genipin. Oyo Yakuri 1980;19:259-267.
2.    Harada M, Tenmyo N, Aburada M, et al. Pharmacological studies on Gardeniae fructis. I. Effects of geniposide and genipin on the biliary excretion, the gastric juice secretion, and the gastric contraction, and other pharmacological actions. Yakugaku Zasshi 1974;94:157-162.
3.    Hou YC, Tsai SY, Lai PY, et al. Metabolism and pharmacokinetics of genipin and geniposide in rats. Food Chem Toxicol 2008;46:2764-2769.
4.    Sung HW, Huang RN, Huang LL, et al. In vitro evaluation of cytotoxicity of a naturally occurring cross-linking reagent for biological tissue fixation. J Biomater Sci Polym Ed 1999;10:63-78.