Novobrace FAQs

1. What is Novobrace?

Our patented technology, Novobrace, is a chemically made internal brace formed by injection of a crosslinking agent directly into the tendon or ligament, immediately adding mechanical support to the injury. This newly formed, flexible brace prevents further propagation of the lesion, provides better stronger healing, and results in the horse returning to full work significantly faster. Crosslinking therapy has also been shown to increase nutritional support to avascular tissues (like tendons); improving nutritional status facilitates the natural healing process. Novobrace may be used as a standalone therapy and also as an adjunct therapy with other tissue healing therapies including stem cells and growth factors. Unlike many other treatments commonly used by veterinarians to treat such injuries, Novobrace does not depend on a biological response or the animal’s immune system for efficacy and can dramatically reduce recovery time for the horse.

Thorougbred Bluegrass Kentucky Horse Stem Cell PRP Regnerative Therapy

2. Is there research to support the use of Novobrace?

Yes. Over one hundred horses have been successfully injected with Novobrace to date. Numerous articles have been published on the Novobrace technology, Nonsurgical Exogenous crosslink Therapy, and are listed on our website. In fact, the main ingredient in Novobrace is currently being investigated for the treatment of spinal disc disease in humans and has undergone extensive research in this area. Several studies have been performed testing the product on equine tendons. Both in the lab and in the field, Novobrace has shown efficacy with minimal side-effects. Additionally, the largest clinical study is currently in the process of being reviewed by a well respected veterinary journal.

3. How is Novobrace different than PRP or Stem cells?

Cell-based treatment approaches (conventional tissue engineering, stem cells, cytokines, gene therapy) categorically require a long period of protected loading to facilitate the necessary biological repairs. They also rely on the presence of adequate nutrition to support the increased biological demand of the therapy. Considering the limited blood supply to many load supporting tissues, biological therapies may not be consistently successful without an adjunct treatment capable of improving nutritional conditions while also providing immediate mechanical support. All of these surgical and emerging biological techniques would also benefit from a treatment capable of bolstering the strength of other connective tissues in the vicinity of the injury by supporting healing processes while minimizing re-injury risk from non-compliant animals during the long healing process. During normal healing of tendons and ligaments, crosslinks (which provide the ultimate strength to these load bearing tissues) are the last to develop and can take up to a year to form. This is why Cell-based treatments recommend a lengthy 12-18 month return to work rehab schedule.

4. What is the procedure for treating tendon injuries with Novobrace?

Once the product is reconstituted according to the label directions, injection of Novobrace is done under standing sedation with a sterile preparation. Ultrasound guidance is used to carefully place a small amount (0.3mL Maximum per injection site) into and around the lesion. This product forms a collagen brace, meaning the use of Novobrace is very different than any other injectable tendon product. The idea behind the use of this product is to inject a very small amount where you want the tendon to have more support. Generally, we recommend placing 0.2mL about 3cm above the core lesion, 0.2mL in the lesion, and 0.2mL about 3cm below the lesion. After injection, it is best to keep a bandage on the leg for the next 3-5 days. These are just general recommendations; review the package insert and available online documentation for further direction. Additionally, we encourage you to consult with our field service veterinarians to discuss your case. There is no additional fee for this service. For consultation on your specific case, contact the Novobrace Vetline at 1.844.859.NEXT (6398).

5. How quickly does Novobrace work?

The Novobrace therapeutic effect begins within 30 minutes of application and is complete within 24 hours, allowing the horse to benefit from the stabilized tissue almost immediately. Novobrace therefore helps tremendously with equine compliance issues during recovery. Our treatment significantly reduces the cost of treatment by reducing recovery time and increasing the likelihood of full recovery and return to work or competition when used either as a stand-alone or adjunct to other treatments.

6. What are the side effects of Novobrace?

Novobrace has minimal side effects and has low toxicity. Side effects include swelling at the injection site, mild and transient general inflammatory response which can be treated with an NSAID and/or regional limb perfusion with an antibiotic and steroid. These side effects are more commonly noted on white/gray legs. Studies conducted to date include: in vitro cytotoxicity experiments, subcutaneous injection studies (rats & horses with clinical observation, blood chemistry, histopathology of injection site, 2-day, 15-day), intratendinous (rabbit Achilles, horse SDFT), and neurotoxicity (epidural worst case injections in rats, 2 hour, 72 hour, with a battery of functional observational evaluations).